Dharadhar,S.; Majumdar,A.; Dhoble,S.; Patravale,V. DrugDev.Ind.Pharm. 2019, 45, 188–201. doi:10.1080/03639045.2018.1539497 Xin,G.; Zhang,M.; Zhong,Z.; Tang,L.; Feng,Y.; Wei,Z.; Li,S.; Li,Y.; Zhang,J.; Zhang,B.; Zhang,M.; Rowell,N.; Chen,Z.; Niu,H.; Yu,K.; Huang,W. ACSAppl.Mater.Interfaces 2020, 12, 57710–57720. doi:10.1021/acsami.0c17296 When the needles create microscopic punctures in the skin, it triggers the body’s natural wound healing process, which promotes cell turnover, boosts collagen production and helps to reduce future acne breakouts. The punctures also allow any treatments or serums that have been applied before microneedling (such as vitamin C or hyaluronic acid) to reach the deeper layers of the skin. Amodwala,S.; Kumar,P.; Thakkar,H.P. Eur.J.Pharm.Sci. 2017, 104, 114–123. doi:10.1016/j.ejps.2017.04.001 Grumezescu,A.M. Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology; William Andrew, 2017.

Al-Kinani,A.A.; Zidan,G.; Elsaid,N.; Seyfoddin,A.; Alani,A.W.G.; Alany,R.G. Adv.DrugDeliveryRev. 2018, 126, 113–126. doi:10.1016/j.addr.2017.12.017 Prausnitz,M.R.; Jiang,J.; Patel,S.R.; Gill,H.S.; Ghate,D.; McCarey,B.E.; Geroski,D.H.; Edelhauser,H.F. Invest.Ophthalmol.VisualSci. 2007, 48, 3191. Formulated using 39% Hyaluronic Acid, the patches are ideal for restoring lost moisture for a deeply hydrated finish. To help your skin absorb this all the more efficiently, both low and high molecular weights of Hyaluronic Acid has been added to ensure maximum efficacy in dispelling signs of dehydration and dryness. A nourishing Hexapeptide Complex helps you to avoid crepe-like textures, with Acetyl Hexapeptide-8 working to relax the beginnings of fine lines, delaying their progression into deeper wrinkles. Heptapeptide-7 has firming properties to lessen the impact of sagging for a more energetic look and feel.Kusama,S.; Sato,K.; Matsui,Y.; Kimura,N.; Abe,H.; Yoshida,S.; Nishizawa,M. Nat.Commun. 2021, 12, 658. doi:10.1038/s41467-021-20948-4 Vision impairment and blindness https://www.who.int/news-room/fact-sheets/detail/blindness-and-visual-impairment (accessed Jul 19, 2022). Undaria Pinnatifida Extract and Corallina Officinalis Extract Revitalizing natural extracts with plumping capabilities to help smooth crow’s feet and restore suppleness, while improving elasticity and tone. The length of the microneedles makes a huge difference. Longer needles can get into the dermis, which is why you might’ve seen microneedling videos online where there’s a ton of blood. But shorter microneedles can be designed to go deep enough to get past the dead stratum corneum, but not so deep that you can feel any pain or end up with any bleeding. How do dissolving microneedles work? I absolutely love these! They have been a godsend for my undereyes. I could not be more impressed. These patches are incredibly easy to use and provide noticeable results.

Lee,Y.; Park,S.; Kim,S.I.; Lee,K.; Ryu,W. Adv.Mater.Technol.(Weinheim,Ger.) 2020, 5, 1901145. doi:10.1002/admt.201901145

I’ve been using Eye Rejuvenator over the last 6 weeks. I love how easy the patches have been to use and incorporate into my routine. You literally peel them off gently push them and you can feel the MicroCrystals working. I can see the improvement the plumping of my lines and my eye area looks more awake and alive. deGroot,A.M.; Platteel,A.C.M.; Kuijt,N.; vanKooten,P.J.S.; Vos,P.J.; Sijts,A.J.A.M.; vanderMaaden,K. Front.Immunol. 2017, 8, 10.3389/fimmu.2017.01789. doi:10.3389/fimmu.2017.01789 Wróblewska,K.B.; Milanowski,B.; Kucińska,M.; Plewa,S.; Długaszewska,J.; Muszalska-Kolos,I. Pharmaceuticals 2021, 14, 849. doi:10.3390/ph14090849

Park KY, Kwon HJ, Lee C, et al Efficacy and safety of a new microneedle patch for skin brightening: a randomized, split-face, single-blind study, J Cosmet Dermatol 2017, 16, 382–387. DOI: 10.1111/jocd.12354 Kim,N.J.; Harris,A.; Elghouche,A.; Gama,W.; Siesky,B. Ocular Permeation Enhancers. In Nano-Biomaterials For Ophthalmic Drug Delivery; Pathak,Y.; Sutariya,V.; Hirani,A.A., Eds.; Springer International Publishing: Cham, 2016; pp177–209. doi:10.1007/978-3-319-29346-2_9 Heikal,M.A.; Soliman,T.T.; Abousaif,W.S.; Shebl,A.A. Graefe'sArch.Clin.Exp.Ophthalmol. 2022, 260, 353–361. doi:10.1007/s00417-021-05356-0

The microneedles contain ingredients that act to kill acne bacteria and decrease inflammation, two of the main factors that cause acne.The ingredients in the patches include: Cometto-Muñiz,J.E.; Cain,W.S.; Hudnell,H.K. Percept.Psychophysics 1997, 59, 665–674. doi:10.3758/bf03206014