Jim Cummings ( Shocker in Spider-Man: The Animated Series) voices Kraven the Hunter, Noir Goblin, Noir Boomerang, and Tinkerer. Gilvezan previously voiced Peter Parker in the 1981 animated series Spider-Man and His Amazing Friends. Steve Blum (several characters in The Spectacular Spider-Man as well as Wolverine in various media outlets) voices Hobgoblin 2099, Silvermane 2099, Noir Vulture, and Vulture 2099.

When it is shattered into pieces during a fight between the Amazing Spider-Man and Mysterio, it causes problems with multiple realities across the Marvel Multiverse. It received generally positive reviews from critics, who praised the concept of bringing four Marvel universes together, and lauded the voice acting, combat, presentation, humor, and score. A different character who took up the Spider-Man mantle in the future, Miguel O'Hara is forced to contend with the machinations of the evil Alchemax corporation in addition to facing off against future versions of Spider-Man enemies: Hobgoblin, Scorpion, and Doctor Octopus. The Ultimate Spider-Man battles Electro to prevent him from destroying a hydro-electric dam, where the latter uses his fragment to grow larger and more powerful as he absorbs more energy. Madame Web uses her psychic abilities to keep the suit from overwhelming and corrupting young Peter.Metacritic gave it a score of 73 out of 100 for the DS version; [28] 74 out of 100 for the PlayStation 3 version; [29] 76 out of 100 for the Xbox 360 version; [31] 75 out of 100 for the Wii version; [30] and 68 out of 100 for the PC version. Gregg Berger (Kraven the Hunter and Mysterio in Spider-Man: The Animated Series, Kingpin in Spider-Man: Web of Shadows), Rodger Bumpass (Doctor Octopus in The Amazing Adventures of Spider-Man), Chris Edgerly (Spider-Man in The Amazing Adventures of Spider-Man), Nick Jameson ( Morbius, the Living Vampire and Richard Fisk in Spider-Man: The Animated Series), Keith Szarabajka ( Wolverine in Ultimate Spider-Man, Venom in Spider-Man: Web of Shadows, and a Kingpin henchman in Spider-Man: The New Animated Series), James Arnold Taylor (Spider-Man in Spider-Man: Friend or Foe and Spider-Man: Battle for New York, Mysterio in Spider-Man 2, Electro in Ultimate Spider-Man, and Harry Osborn and Frederick Foswell in The Spectacular Spider-Man), and Dave Wittenberg (additional voices in Ultimate Spider-Man) voice different characters throughout the game. Prior to playing Spider-Man himself, Keaton also voiced Peter's best friend Harry Osborn in various video games ( Spider-Man, Spider-Man 2, and Spider-Man: Friend or Foe), and would later play Electro in Insomniac's Spider-Man, as well as Norman Osborn, John Jameson and Steel Spider in Marvel's Spider-Man.

During specific parts of the boss battles, Shattered Dimensions switches to a first-person perspective, where the player can use the analog sticks (or the Wii Remote and Nunchuk in the Wii version) to control Spider-Man's arms, punching their opponent and dodging their attacks. In his universe, Ultimate Spider-Man is forced to face off against Electro, Deadpool, and Carnage before joining the final battle against Mysterio. Shattered Dimensions was re-released via Steam on October 24, 2015, but was later removed on April 1, 2017.Spider-Man: Shattered Dimensions is a 2010 action-adventure video game based on the Marvel Comics superhero Spider-Man, developed by Beenox and published by Activision.

The Amazing Spider-Man is captured by Kraven the Hunter and taken to a jungle, where he is forced to overcome a series of trials for a fragment. GamesRadar gave it three-and-a-half stars out of five and said " Shattered Dimensions is a good game, but it fell short of an Ultimate Marvel Team-Up". This version also omits Ultimate Spider-Man, and features less villains: Electro and the Tinkerer for the Amazing Spider-Man; Boomerang and Calypso for Spider-Man Noir; and Vulture and Silvermane for Spider-Man 2099.com gave it a B and stated, " the change in combat options is a welcome addition, I just wish that the story had delivered on the comic legacy of one of Marvel's more enduring heroes".