It’s used more frequently in supplements, as it’s considered more stable and cost effective than other forms of vitamin B12.

Birth control pills can also deplete several B vitamins, including B6, B12, folate, and riboflavin ( 26). Summary Optimum support - Methylated forms of B vitamins have been shown to be better absorbed and used by the body Although these vitamins share some characteristics, they all have unique functions and are needed in different amounts. Methyl B Complex delivers all eight water-soluble B-vitamins in their bioavailable forms together with co-factors. B2 (riboflavin). Riboflavin helps convert food into energy and also acts as an antioxidant. Foods highest in riboflavin include organ meats, beef, and mushrooms ( 2).

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One study found that supplementing with a vitamin containing B12, B6, and folic acid led to a more enhanced and lasting antidepressant response over 1 year, compared with a placebo ( 30). Additionally, the MTHFR genetic mutation can affect how your body metabolizes folate, which can lead to a folate deficiency and other health concerns ( 21). Some studies suggest that your body may absorb cyanocobalamin slightly better than methylcobalamin. While certain conditions make it necessary for some people to supplement with B-complex vitamins, research has shown that taking a B vitamin supplement may be helpful even for people who don’t have an increased need for these nutrients. May reduce stress and boost mood Beat stress and tiredness, increase energy levels, ensure normal homocysteine metabolism and optimal methylation, folate and transsulfuration cycles with Methyl B Complex!

Unlike cyanocobalamin, methylcobalamin is a naturally occurring form of vitamin B12 that can be obtained through supplements, as well as food sources like fish, meat, eggs, and milk ( 3, 4). SUMMARY B vitamins may also enhance treatment response when given in combination with antidepressant medication. When you ingest cyanocobalamin, it can be converted to both of the active forms of vitamin B12, methylcobalamin and adenosylcobalamin.B1 (thiamine). Thiamine plays an essential role in metabolism by helping convert nutrients into energy. The richest food sources include pork, sunflower seeds, and wheat germ ( 1). As you age, your ability to absorb vitamin B12 decreases and your appetite declines, making it difficult for some people to get enough B12 through diet alone.

B12 or folate deficiency during pregnancy or while nursing can lead to severe neurological damage or birth defects in the fetus or infant ( 10). Older adults Methylation requires a specific B vitamin to be present in the body – 5-MTHF (also known as methylfolate). In rare cases may cause temporary skin flushing, tingling, and/or itching, especially when taken on an empty stomach. This is a natural and harmless reaction.High doses of supplemental B3 (niacin) may lead to vomiting, high blood sugar levels, skin flushing, and even liver damage ( 34). While another essential nutrient, choline, was formerly considered to be a B-complex vitamin and shares some similarities with them, it is in fact neither a vitamin nor a mineral. Summary Supplementing with active B vitamins is important for everyone, and especially when there’s a risk of vitamin malabsorption for individuals with: Deficiencies in vitamin B6 and folate are also common in older adults ( 14, 15). Those with certain medical conditions When cyanocobalamin enters your body, it’s converted into either methylcobalamin or adenosylcobalamin, which are the two active forms of vitamin B12 in humans ( 1).

A daily B-complex vitamin can help ensure that people who choose to follow diets that eliminate animal products are getting enough of these important nutrients. People taking certain medications Some researchers recommended treating vitamin B12 deficiencies with either cyanocobalamin or a combination of methylcobalamin and adenosylcobalamin due to distinct properties of these latter two forms ( 9). SUMMARY A 33-day study in 215 healthy men found that treatment with a high dose B-complex and mineral supplement improved general mental health and stress and enhanced performance on cognitive tests ( 27).Superior - Some individuals are less able to efficiently convert folic acid to methylfolate due to genetic variations in the activity of the MTHFR enzyme, therefore taking methylfolate is a more effective option for everyone