The fourth stage is the speed increase to 6.8 km / h and the treadmill inclination 16%, and the last stage 5 is the speed of 8 km / h and the inclination of the treadmill 18%. Twice (during the initial and final stages) the following measurements were taken: complete blood count with smear, fasting glucose, total cholesterol, HDL, LDL and triglycerides, sodium, iron, potassium, magnesium, serum calcium, determination C-reactive protein (CRP) concentrations. Visit 2 - month 0. Randomization visit. (within 3 ± 1 days of the visit 1) Fasting state. Blood pressure, heart rate, body mass index (BMI) measurements, waist-hip ratio (WHR).

Atsma F., Bartelink M.L., Grobbee D.E., van der Schouw Y.T. Postmenopausal status and early menopause as independent risk factors for cardiovascular disease: A meta-analysis. Menopause. 2006;13:265–279. doi: 10.1097/01.gme.0000218683.97338.ea. kapsułka dopochwowa zawiera łącznie 1,65×10 9 CFU/g Bifidobacterium bifidum W28, Lactobacillus acidophilus W70, Lactobacillus brevis W63, Lactobacillus helveticus W74, Lactobacillus plantarum W21, Lactobacillus salivarius W24;

Rahman T., Hosen I., Islam M.M.T., Shekhar H.U. Oxidative stress, and human health. Adv. Biosci. Biotechnol. 2012;3:997–1019. doi: 10.4236/abb.2012.327123. Store this product in the refrigerator, do not freeze. Heat or humidity may affect the live bacteria in this product, making it less effective.

produkt należy stosować zgodnie z instrukcją, przez 5 dni od dnia zakończenia miesiączki wieczorem przed snem; In the composition of the preparation there are 8 bacterial strains with the key functions for the efficiency of the intestinal barrier. The most active bacterial cultures present in the preparation are B. Bifidium and L. Casei, which strengthen immunological functions of the intestinal barrier, stimulate the immune response by intensifying the synthesis of interleukin 10 and inhibit the activity of mastocytes. This last functionality is also demonstrated by the stains L. Salivarius present in the supplement. Bacteria L. Acidophilus and Lc. Lactis additionally reduce the burden with polysaccharides. B. lactis and L. brevis are in turn one of the strongest strains positively influencing mechanical tightness of mucous membrane. Visit 10 - month 8 (4 weeks ± 3 days from the visit 9) Fasting state. Blood pressure, heart rate, BMI measurements, WHR. Blood collection for zonulin and immunoglobulins against zonulin, calprotectin, CRP, HbA1c, HGB, RBC, WBC, PLT, creatinine, lipogram, ALT activity and oxidative stress parameters (SOD, GPx,CAT, GR, TOC, LPS, PSH, MDA, GSH, TAS (TAC).) . Inflammatory state will be assessed by measurement of blood C-reactive protein (CRP) as well as blood and stool calprotectin.During the test, the maximum test procedure was used to obtain more test parameters, and the test condition was considered to be 90% HRmax by the test subject, or the test could not be continued by interrupting it at the test subject's request. Third visit took place at the Hematological Diagnostics Department of the University Teaching Hospital in Bialystok, where from each participant the blood was collected (from the vein) in an amount of 10 ml for biochemical tests (as during the initial stage at visit 3).

Forslund K, Hildebrand F, Nielsen T, Falony G, Le Chatelier E, Sunagawa S, Prifti E, Vieira-Silva S, Gudmundsdottir V, Pedersen HK, Arumugam M, Kristiansen K, Voigt AY, Vestergaard H, Hercog R, Costea PI, Kultima JR, Li J, Jorgensen T, Levenez F, Dore J; MetaHIT consortium, Nielsen HB, Brunak S, Raes J, Hansen T, Wang J, Ehrlich SD, Bork P, Pedersen O. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota. Nature. 2015 Dec 10;528(7581):262-266. doi: 10.1038/nature15766. Epub 2015 Dec 2. Erratum In: Nature. 2017 May 3;545(7652):116. Visit 8 - month 6 (4 weeks ± 3 days from the visit 7) Gastrointestinal symptoms questionnaire administration.

Jak stosować kapsułki Sanprobi Barrier?

For morphological tests (blood count with smear, lipid profile, fasting glucose, C-reactive protein and ionogram) at the third visit for each competitor was collected blood from the vein in the amount of 10 ml.

The energy value of the daily nutritional plan, the content of the main nutrients, vitamins, minerals, cholesterol and dietary fiber were taken into account in the evaluation of the three-day nutrition diary.W produkcie nie wykryto kazeiny (granica wykrywalności 0,06 mg/kg), odtłuszczonego mleka w proszku (granica wykrywalności 1,0 mg/kg), β-laktoglobuliny (granica wykrywalności 2,0 mg/kg). It included qualification for the study based on the criteria for inclusion in the study group, discussion of the purpose of the study and signing the written consent for the study by the participants, as well as information about the protection of their personal data and full anonymity. The intestinal barrier creates a protective wall between the human body and the outside world. Its most important task is the proper selection and absorption of nutrients beneficial for health, protection against toxins and their elimination from the body, preventing the entry of pathogens from the gastrointestinal tract into the body. In addition, the intestinal barrier performs important physiological functions in the human body, therefore the disruption of its structure can lead to increased permeability, promote the overloading of the immune and nervous system. Patient will be cross-over to the different group of probiotic/placebo ("A" or "B" as described on the visit 2) and will be advised to consume 2 capsules in the morning and 2 capsules in the evening.