This prescribable all-in-one system – attached to a pot of 50x GlucoRx Nexus Glucose Test Strips – is convenient enough to fit in bags used by Doctors, District nurses and Paramedics.

Glucose 50% w/v is for administration by intravenous infusion following appropriate dilution or incorporation in to a parenteral nutrition admixture.The general strategy for the synthesis of diosgenyl 2-amino-2-deoxy-β- d-glycopyranoside (diosgenyl β- d-glucosaminoside, DsO-β- d-Glc-NH 2) relies on the preparation of an appropriately protected glycosyl donor, next, a coupling of the donor with diosgenin and finally, the deprotection of the amine and hydroxyl groups of the obtained diosgenyl glycoside. A properly protected amino group located at the C-2 atom of the glycosyl donor can play a key role in a glycosidic coupling, e.g., amide-type groups participate in the process of bond forming as the neighbouring group, which favours the formation of a 1,2- trans-glycosidic bond [ 38]. Therefore, among other things, various N-protecting groups were developed for the synthesis of diosgenyl–carbohydrate conjugates.

The above effects do not only result from the administration of electrolyte-free fluid but also from glucose administration. Bisher sind jedoch keine Wechselwirkungen mit anderen Arzneimitteln bekannt. Schwangerschaft und Stillzeit Hydrochloride of diosgenyl β- d-glucosaminoside ( 11 .HCl) was the first diosgenyl glycosaminoside which has been tested for cytotoxic activity. Importantly, this compound does not exhibit antiproliferative activity against non-tumoral cells—peripheral lymphocyte blood cells [ 48]. Further antitumor tests on 11 .HCl determined its independent effect and in combination with 2-chlorodeoxyadenosine (2-CdA, cladribine) on lymphocytes isolated from the patients suffering from chronic B-cell lymphocytic leukemia (B-CLL) [ 41]. It was found that this saponin is cytotoxic towards B-CLL—it induces apoptosis and necrosis of some leukemic B-cells. Additionally, 11 .HCl enhances the cytostatic effect of 2-CdA, significantly reducing (20–30%) the number of lymphatic cancer cells in some patients. This could indicate that the tested saponin increases B-cell membrane permeability and facilitates the penetration of the drug into the tumor cell. In turn, in in vitro studies on the other tumor cells, including cervical carcinoma cells—HeLa, CaSKi, ViBo—and human leukemia cells—HEL, K562, HL60 and melanoma WM9—were conducted. The hydrochloride of 11 shows only a moderate antiproliferative effect (IC 50 ranging from 10.7 to 41 µM) [ 48, 49]. However, it is worth adding that 11 .HCl shows better inhibitory activity toward the tested cancer cell lines than the starting material, which is diosgenin (IC 50 values 63.8–81 µM) [ 49].

Technical data, MSDS & samples

The infusion must be stopped immediately if any signs or symptoms of a suspected hypersensitivity reaction develop. Appropriate therapeutic countermeasures must be instituted as clinically indicated. When selecting the type of infusion solution and the volume/rate of infusion for a geriatric patient, consider that geriatric patients are generally more likely to have cardiac, renal, hepatic impairment, and other diseases or concomitant drug therapy.

Saponins have the characteristic ability to reduce the surface tension of aqueous solutions and maintain a stable foam [ 5]. Therefore, they are useful in the production of emulsions and cleaning agents [ 5]. Most of them have been extracted from herbal preparations used in folk medicine, especially in Asian countries. In the form of herbal extracts, ointments, and various types of infusions, they are used as anti-malarial drugs, antidotes against snake and insect venoms, and as antiseptics, bactericides and antivirals [ 6]. Saponins also present interesting pharmacological properties, such as anti-diabetic [ 7, 8, 9], anti-cancer [ 10, 11, 12] and anti-inflammatory [ 13, 14, 15, 16], and specific physiological properties—they change the structure of cell membranes, making them more permeable to compounds [ 17]. Saponins can also impair the digestion of intestinal proteins and the absorption of vitamins and minerals [ 18]. Informieren Sie Ihren Arzt oder Apotheker, wenn Sie andere Arzneimittel einnehmen/anwenden, kürzlich andere Arzneimittel eingenommen/angewendet haben oder beabsichtigen, andere Arzneimittel einzunehmen/anzuwenden.

Quick tips

Glucobay 50 Tablet is used to treat people with type 2 diabetes mellitus. It helps lower blood sugar levels after meals. It belongs to a group of medicines known as alpha-glucosidase inhibitors. This medicine is usually prescribed in combination with other diabetes medications. Presented syntheses were aimed at finding semi-natural diosgenin derivatives with favorable pharmacological properties. A wide range of such derivatives is presented, which makes it difficult to discuss the influence of specific modification on pharmacological properties. However, some conclusions can be made. When using an infusion pump all clamps on the intravenous administration set must be closed before removing the administration set from the pump, or switching the pump off. This is required regardless of whether the administration set has an anti-free flow device. water and electrolyte disturbances that could be aggravated by increased glucose and/or free water load (see above).

Manche individuell anzufertigende Arzneimittel (Rezepturen) sind bei DocMorris nicht erhältlich bzw. ihre Anfertigung kann länger dauern. Bitte wenden Sie sich vor Bestellung einer Rezeptur an unseren Kundenservice. MIC 50 (MIC 90) = minimum inhibitory concentrations (µg/mL) at which 50% and 90% of the isolates were inhibited, respectively. ** n is the number of tested isolates of a given pathogen. Glycosyl chlorides ( 24– 27) and ( N-phenyl)trifluoroacetimidates ( 28– 31) with different protecting groups at the 2-amino function.Children, the elderly, women, postoperative patients, patients with hypoxia and patients with central nervous system disease or psychogenic polydipsia are at particular risk for this complication. A series of N-alkyl and N,N-dialkyl derivatives of diosgenyl 2-amino-2-deoxy-β- d-gluco- and d-galactopyranosides have been synthesised [ 50, 54]. The synthesis of these compounds used a method of reductive alkylation of amines [ 61]. N-Monoalkyl derivatives were obtained by treatment of the primary amine group in diosgenyl β- d-glycosaminoside with an appropriate aldehyde ( R-CHO), followed by reduction in the resulting imine with sodium cyanoborohydride (NaBH 3CN). Unverbindliche Preisempfehlung des Herstellers (UVP). Bei zu Lasten der Krankenkasse abgegebenen Produkten: Apothekenerstattungspreis gemäß ifap Service-Institut für Ärzte und Apotheker GmbH, Stand 15.11.2023, d.h. Abrechnungspreis zulasten der gesetzlichen Krankenkassen nach § 129 Abs. 5 SGB V i.V.m. der Arzneimittelpreisverordnung, abzüglich eines Abschlags in Höhe von 5% zugunsten der Krankenkasse. None of the tested derivatives of diosgenyl glycosaminosides are effective against G‒ bacteria. This finding confirms the known fact that saponins do not exhibit such activity. Aus mikrobiologischen Gründen sollten Mischungen mit Zusätzen oder anderen Injektions- oder Infusionslösungen sofort verwendet werden. Falls sie nicht sofort verwendet werden, liegen Aufbewahrungszeiten und -bedingungen in der Verantwortung des Anwenders. Normalerweise sollten Mischungen nicht länger als 24 Stunden bei 2 °C – 8 °C gelagert werden, falls sie nicht unter kontrollierten Bedingungen und Gewährleistung von Keimfreiheit hergestellt wurden.