Your prescription form, dose, and how often it’s administered will depend on your reason for taking it. The form of administration varies with estrogen therapy and depends on the specific symptoms the treatment is targeting. Essentially, certain symptoms, such as the vasomotor symptoms experienced during menopause, would best be controlled with estrogen therapy that acts systemically. Conversely, symptoms involving the vaginal lumen, such as dyspareunia, vaginal itching, and vaginal dryness, experience more control with locally acting estrogen therapy. Typically, women with an intact uterus receive combination estrogen and progesterone therapy. Women who have had hysterectomies receive estrogen alone. Usually, estrogen therapy divides into two main routes administered either orally or transdermally. Both men and women produce estrogen, but it’s usually considered a “female hormone” because men have smaller amounts in their bodies. Ashwagandha / Withanolides: This is a tough one. According to the 3rd party testing done by ConsumerLabs, the majority of ashwagandha supplements don't contain enough withanolides to be clinically relevant. Furthermore, about 50% of supplement companies are making dishonest claims regarding withanolide content. Withanolide is the active ingredient in ashwagandha and clinical studies that find benefits from ashwagandha usually use at least 10 mg of withanolide per day. Nature's Way has by far the most withanolides (90 mg per capsule despite claiming to "only" have 20 mg) but Nature's Way is not organic. Organic ashwaganda is important to me because studies have shown major amounts of pesticides and herbicides in ashwagandha supplements, including a hefty blast of atrazine ( ref) which acts like estrogen in our body. Anyway, Organic India Ashwagandha ranks best overall in my estimation but you'll need to take 4 pills per day, instead of the recommended 2, if you want the full clinical potential. Start with a fairly low dose (e.g. 1 pill) because some people get itches and rashes from withanolides - mostly people with the BCHE gene issue that are sensitive to nightshade plants. Here is the Organic India Ashwagandha LINK

Amylopectin (Branched/Complex Glucose) Carb Powder: For bulking and very specific athletic applications, I recommend Waxy Maize, NOW, LINK Here and throughout this book, I will be calling this list the Ill Reproductive System List, or IRS List. As mentioned, this list is so named because I believe reproductive infertility is the most significant tragedy relating to these artificial substances.Next, in Part 2: Rising Disease, severe health problems arising from eating or drinking estrogen-like items will be unveiled. These are health problems on the very cutting-edge of scientific discovery and you will see how the problems impact both humans and unbelievable numbers of wildlife species. I also appreciated that he discussed how condensed Sesame paste is obviously going to be more estrogenically potent then plain Sesame seeds. That's obvious when you think about it but many people wouldn't have. Sesame seeds are okay. Most foods are okay in moderation. But some foods are considerably worse than others when you look at the whole. Vitamin B3 (Niacin): Life Extension, 800 milligrams, LINK. If you have too much flushing from regular niacin but you still want to lower LPA, use 500 mg of Niacinamide, L INK. For a second dairy-free option, I also like Natural Force "Organic Bone Broth" protein (especially if you have histamine issues and collagen elevates those issues). I especially like the chocolate flavor, LINK If you take any of the medications or supplements listed above under the vaginal ring, the patch may be less effective.

DARLENE: Well, I know we've been kind of talking about excess estrogens for a number of years, but I think people kind of go, “Oh yeah, well it's just those nutritionists, you know?” Mono-Species: Life Extension, Bifido Gi Balance [ Bifidobacterium longum is another probiotic to try if you have histamine issues and a high number of food sensitivities ( ref)] LINK And I've been a Licensed Nutritionist in the state of Minnesota since 1996; actually when they started licensing. Listened to the audio book. I liked that serious topics were presented by telling a personal story first, it helped in keeping it interesting and not overloading the brain with all the scientific info all at once. This book is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

Oxytocin: I've heard amazing things about this product from a client with the oxytocin receptor genetic issue, OxyLuv, Oxytocin Nasal Spray, LINK. You can also be extra cautious and get a product from a compounding pharmacy (prescription grade). In academia, Dr. Jay earned a Ph.D. in Biochemistry from Boston University School of Medicine and earned a B.A. with a double major in Biology and Theology from Ave Maria University, Florida. His professional scientific work has been published in leading medical and science journals and presented at global venues such as the International Conference on Alzheimer’s Disease (ICAD) in Vienna, Austria, or the Kern Lipid Conference in Vail, Colorado, where Dr. Jay received the “Early Career Investigator Award” in 2014. Electrolytes: A few years ago, all you could find for electrolyte pills/powders was salt with sugar. To make matters worse, the salt often was industrially processed crap with aluminum (a neurotoxin) or sea salt containing microplastics galore. Yet, for keto diets and heavy/long sweat sessions, good quality electrolyte complexes are tremendously important. They'll prevent cramps and nausea. They prevent or at least help with "keto flu". For pills, I like Hi Lyte, LINK. More recently, I've moved away from pills and started using electrolyte powders simply because they taste amazing. I love Robb Wolf's LMNT electrolyte powders and he has many excellent flavors LINK. I also love Clovis Hydration Drink Mix, LINK. Be aware if you are super sensitive to heart palpitations, the potassium in all of these may be an issue for you. Are flax and soy "health" foods? Are vinyl cribmattresses giving off "estrogenic emissions"? What about sunscreens and soaps? Red 40 food coloring? Grains?! Estrogenerationis the captivating adventure story of young Anthony Jay moving to Florida, meeting his future wife Allison, and becoming swept up with Allison in the pursuit of a giant tarpon fish. It is also a tale of "natural" versus "unnatural" as Anthony discovers and identifies specific artificial estrogens in his everyday environment. Selenium: Another excellent thyroid supplement is selenium (along with iodine and L-tyrosine), Trace Minerals 300 mcg liquid dropper, LINK

Estrogen is a group of hormones produced by a woman’s ovaries and, to a lesser degree, by the adrenal glands, fat tissues, and a man’s testes. It is considered a sex hormone because it is produced by the reproductive organs and affects these organs, too. ( 1) ANTHONY: Yeah, phthalates are another one that are related to BPA, right, because they're also in a lot of plastics. Plastics are problems.If you are dairy sensitive (unfortunately, "Steak Shake" has some whey protein), I recommend and use Primal Kitchen "Collagen Fuel" grass fed collagen protein powder, which also tastes excellent, LINK. DARLENE: Because we want it to be something that will help you achieve better health. You know, I, we have a topic today I think you're going to really appreciate learning about because we have invited a hormone expert. And his name is Anthony Jay and he's going to join us this morning and share some really important information. You know, just a few months ago I received a copy of his book; this fascinating book; and you know, if I think a book is fascinating and worth sharing with you, then it must be good. And this is a good book to read. L-Histidine: For that rare filaggrin gene issue that leaves skin dry and scaly, L-Histidine is the most targeted supplement fix I know of ( ref). I like BulkSupplements L-Histidine HCl Powder and the study linked above used 4 grams per day, LINK.Based on this study ( ref), I've also seen people test this organic Perilla Seed Oil, LINK, with great success. Studies also suggest mugwort may also be useful ( ref) as well as Chameleon Plant ( ref). Worth nailing this down - when you have decreased filaggrin, your skin is more susceptible to colonization of bad bacteria and microorganisms that trigger the immune system ( ref ref). Ok. So let’s blast right into defining estrogenics as I promised. Estrogenics sounds like a cross between estrogen and genetics but what does it mean? Birth control pills contain estrogen in combination with a form of progesterone. Depending on the brand of oral contraceptive, the medications and dose may vary, and may be taken differently. They also may have different risks and benefits. (8)

ANTHONY: Yeah, so there's a list of them that I put together in my book. It's a top 10 list and we’ll certainly go through some of those. It's kind of an extensive list. On the other hand, your tongue apparently has no leptin receptors. Therefore, leptin just comes and goes in blood circulating around your tongue. It carries no lingual impact. Weird thought but a true story.Looking around, I noticed a handwritten name tag that spelled Dave. It was scrawled in blue-marker. Above the name tag was a friendly face. I walked up, smiled, and introduced myself. From there it was onward and upward; orientation week at Ave Maria University in the sunshine state of Florida. Diindolylmethane (DIM): I generally do not recommend DIM. It often acts like estrogen ( ref, ref, ref) thereby decreasing sperm quality ( ref) and potentially increasing risk of blood clotting issues similar to those seen in birth control users ( ref). If you do decide to use it, experimenting with dose is key because taking too much will cause DIM to act like estrogen but taking the correct amount (different in different people) will decrease estrogen. Strange, I know! The WHI alarmed the medical community in 2002 with study results reporting that, after following participants for a mean of five years, the researchers had moved to stop the estrogen-plus-progestin portion of their study prematurely because the excess risk of breast cancer facing the women taking the drugs made it unethical to continue. ( 5) Regarding plant estrogens: hyper-activating estrogen receptors also leads to a host of health problems, particularly via estrogen receptor alpha. Hence, a number of new synthetic drugs that selectively activate ESR2 over ESR1 (i.e. they activate estrogen receptor beta rather than estrogen receptor alpha) are currently being tested in clinical trials. Examples include diarylpropionitrile and prinaberel and menerba and some other drugs with numbers rather than names to protect pending patents. Anyway, depending on your genetics and epigenetics, plant-based estrogen compounds may work for you but you may need to try more than one. The ones I list below are highly variable person-to-person but at least have minimal activation of the ESR1 (alpha receptor). Favorite: My kids and I love Mark Bell's "Steak Shake" chocolate protein powder because it literally tastes like chocolate milk and has amazing ingredients and Mark is a friend, Mark Bell's Steak Shake, 2.3 lb, LI NK