cooler at 80 minutes by ∼5% for the ice and ∼2% for the gels when compared to baseline but this was not different than the contralateral untreated leg. Washington) and marked for repeat measurements along with cutaneous blood flow from the vastus lateralis. Effects of rest and contralateral influences between treated leg and control leg were examined by using a two factor (condition [menthol gel; contralateral control leg, Placebo Gel; contralateral control leg], 4 × time, 10) repeated measures ANOVA.

Therefore, localized topical application of menthol containing cooling gels may represent a suitable and practical alternative.This, in itself, could have important clinical benefit for treating patients with peripheral neuropathy by increasing cutaneous blood flow to their hands and feet to help with distal sensation. However, the influence of bias on either the participant or investigator will have been minimal due to the objective measurements used while the participant was in the passive rested state and; 4) due to the electrode placement on the vastus lateralis it was difficult to directly massage this region which may have created a bias in measurements, although this was consistent between the 2 gels. This is the first well controlled study to demonstrate that menthol gel increased cutaneous blood flow and reduced intramuscular and skin temperature without any alterations to femoral arterial blood flow and core temperature. Ideal for a congested nose that just wont stop running Tempo Menthol Regular Tissues release a smell of menthol to help you breathe easier. This increased cutaneous flow occurs through activation of TRMP8 receptors in the vascular cells, 12, 13 which in turn increase Nitric Oxide production from the endothelial cells resulting in localized vasodilation.

Therefore, it can be speculated that the menthol induced vasodilation and increased cutaneous flow, as previously described, 11, 12 derives from a diversion of blood from muscle and in doing so may reduce intramuscular temperature. A laser Doppler probe (BL 52, Transonic, Ithaca, NY, USA) was attached to the mid-anterior thigh, midline, halfway between the inguinal line and the patella ( Figure 2B) for the measurement of cutaneous blood flow. We use cookies to personalise content and ads, to provide social media features and to analyse our traffic. Continuous and synchronized pulsed-wave Doppler velocities were also obtained using the ultrasound machine.

Cold therapy is widely used to reduce the amount of soft tissue damage following an acute injury 1 and has been proposed to reduce inflammatory response, haematoma, oedema and pain. The diameter, velocity, and flow were then calculated as the mean of the data acquired across each 30-second period for statistical analysis. Both muscle and skin temperature were then recorded using a hand-held data logger thermometer (HH378, Omega, Manchester, UK) at a frequency of one sample/second. However, the likely cause was from evaporative cooling despite menthol-derived increases in cutaneous blood flow and cooling sensation. Whether you’re battling allergies, soothing a minor irritation, or simply looking for a refreshing pick-me-up, these tissues are your go-to solution.

Given the menthol content of the menthol gel did not cause the observed temperature decline, it suggests that the ethanol content of the gels, similar to the action of sweat, 29 may have increased evaporation 30 to reduce intramuscular and skin temperatures. This effect was not due to the cooling effect of slowing metabolism from rest 28 as these temperatures were still lower than the untreated control leg which also reduced, over the same time period. The images were taken at the superficial femoral artery ∼3 cm distal to the bifurcation ( Figure 2B). From these data, the software calculates blood flow (the product of cross-sectional area and blood flow velocity) at 30 Hz. Then the treatment of either ice pack, menthol-based gel or placebo gel were applied to one thigh while the other thigh was used to control for the effects of rest.The softness and quality of the Renova Sensitive pocket tissue, joined by a subtle menthol perfume to provide a pleasant feeling of freshness and well-being.